Date

The International Conference on Arctic Development, Pollution and Biomarkers
of Human Health has no registration fees, however, people will be asked to
pay for the dinner and reception on Monday evening should they wish to
attend. The conference has a website that is developing and is updated
daily: http://www.niehs.nih.gov/external/arctic

Hotel and travel information can be found on the website.
The registration form: http://www.niehs.nih.gov/external/arctic/form.htm
should be completed and returned to

Ms. Charle League
Office of the Deputy Director
NIEHS (B2-06)
P.O. Box 12233
Research Triangle Park, North Carolina 27709-2233
919-541-5741 telephone
league [at] niehs.nih.gov

Attached below is the Revised Draft Agenda of (3/6/00)

INTERNATIONAL CONFERENCE ON
ARCTIC DEVELOPMENT, POLLUTION AND BIOMARKERS OF HUMAN HEALTH
in coordination with
Arctic Monitoring and Assessment Programme

May 1-3, 2000
Anchorage, Alaska

Sunday, April 30

12:00 noon On-site Registration begins

Monday, May 1

I. Welcome and Opening Remarks
8:30 am Kenneth Olden, National Institute of Environmental Health
Sciences, NIH
8:35 am President Mark R. Hamilton, University of Alaska, Anchorage
8:40 am Marilyn Heiman, Department of Interior
8:45 am Marcia Combes, U.S. Environmental Protection Agency, Region 10
8:50 am Alaska Commissioners

II. Keynote Addresses
A. Economic, Population, and Social Trends in the Arctic
9:00 am Governer Tony Knowles (Invited)

B. Summary of Arctic Monitoring and Assessment Programs
9:10 am Helgi Jensson, Arctic Monitoring and Assessment Programme
9:25 am Andrew Gilman, Health Canada
9:40 am Eva Bonefeld Joergensen, Arctic Monitoring and Assessment
Programme
9:55 am Discussion

C. Scientific Issues in Arctic Health
10:05 am Patricia Cochran, University of Alaska, Anchorage
10:20 am Peter Bjerregaard, National Institute of Public Health,
Denmark (Invited)
10:35 am Discussion

D. Ethical, Legal and Social Implications of Biomarkers Research
10:45 am Richard Sharp, National Institute of Environmental Health
Sciences, NIH

E. Indigenous Peoples on Arctic Health and Lifestyle Panel Discussion
James Berner, Chair
Alaska Native Tribal Health Consortium

11:00 am Christopher Mandregan, Jr., Alaska Area Native Health Service
Paul Sherry, Alaska Native Tribal Health Council (Invited)
Sally Smith, Alaska Native Health Board
Dennis Tiepelman, Inuit Circumpolar Conference-Alaska
Mike Zacharof, Aleut International Association
Rosetta Demoski Alcantra, Yukon River Inter-Tribal Watershed
Council (Invited)
11:25 am Discussion

III. Perspectives on the Arctic Environment
Terri Damstra, Chair
World Health Organization

A. Atmospheric Environment (sources, transport, bioavailability, climate
change)
11:35 am Gunter Weller, Cooperative Institute for Arctic Research
11:50 am Mary Ellen Gordian, University of Alaska, Anchorage
12:05 am Discussion

12:15 - Lunch
1:15 pm

B. Terrestrial Environment (sources, riverine and glacial transport,
bioavailability, future changes)

1:15 pm Maynard M. Miller, University of North Idaho
1:30 pm Cynthia de Wit, Institute of Applied Environmental Research
1:45 pm Discussion

C. Aquatic Environment (sources, transport, influences on food availability,
pathways to human populations)

1:55 pm Anthony Knap, Bermuda Biological Station for Research, Inc.
2:05 pm Carol Folt, Dartmouth College
2:20 pm Richard Handy, University of Plymouth
2:35 pm Discussion

2:45 pm Coffee Break

IV. Exposure Monitoring
David Eaton, Chair
University of Washington

A. Molecular Biomarkers Involving Signal Transduction Systems
3:00 pm Perry Blackshear, National Institute of Environmental Health
Sciences, NIH
3:15 pm Michael Karin, University of California at San Diego
3:30 pm John Kennish, University of Alaska, Anchorage
3:45 pm William F. Greenlee, Chemical Industry Institute of Toxicology
4:00 pm Discussion

B. Molecular Biomarkers in Metal Toxicology
4:10 pm Pierre Ayotte, Quebec Public Health Centre – CHUQ
4:25 pm Thomas W. Clarkson, University of Rochester
4:40 pm Max Costa, New York University
4:55 pm Anatoly Zhitkovich, Williams College
5:05 pm Lawrence Duffy, University of Alaska, Fairbanks
5:20 pm Discussion

5:30 - Roundtable Discussion -- Consensus Building For
6:30 pm Sessions III And IV

7:00 pm Reception
7:30 pm Dinner


Tuesday, May 2

I. Emerging Biomarker Methodologies
Raymond Tennant, Chair
National Institute of Environmental Health Sciences, NIH

A. DNA Biomarkers as Revealed by Molecular Methods
9:00 am Kathleen Dixon, University of Cincinnati
9:15 am Arthur Grollman, State University of New York, Stony Brook
9:30 am Kandace Williams, University of Alaska, Anchorage
9:45 am Bennett Van Houten, National Institute of Environmental Health
Sciences, NIH
10:00 am Discussion

B. Gene Expression-based Approaches
10:10 am Sandy Kennedy, Quintiles England, LTD
10:25 am Richard Smith, Pacific Northwest National Laboratory
10:40 am Coffee Break
10:55 am James E. Trosko, Michigan State University
11:10 am Roger Ulrich, Abbott Pharmaceuticals
11:25 am Stephen Friend, Rosetta Inpharmatics, Inc.
11:40 am Discussion

C. Genetics of Susceptibility to Environmental Factors
11:50 am Fred P. Guengerich, Vanderbilt University
12:05 pm David Eaton, University of Washington
12:20 pm Daniel Nebert, University of Cincinnati
12:35 pm Discussion

12:45 Lunch

VI. Molecular Biomarkers for Disease Related to the Environment
Paivi Peltomaki, Chair (Invite)
University of Helsinki

A. Biomarkers of Neurological, Reproductive, and Organ System Disease
1:40 pm Ann Golden, Mt. Sinai School of Medicine
1:55 pm Robert Roth, Michigan State University
2:10 pm Gayle Windham, California Department of Health Services
2:25 pm Ciaran Regan, University College Dublin
2:40 pm Discussion

B. Biomarkers and Molecular Mechanisms of Carcinogenicity
2:50 pm John DiGiovanni, University of Texas MD Anderson Cancer Center
at Smithville
3:05 pm Lawrence Loeb, University of Washington
3:20 pm Carlo Croce, Thomas Jefferson University
3:35 pm Discussion

C. Disease Biomarkers by Analytical Methods
3:50 pm Lawrence Needham, National Center for Environmental Health,
Centers for Disease Control and Prevention
4:05 pm Kenneth Turtletaub, Lawrence Livermore National Laboratories,
Department of Energy
4:20 pm Michael Denison, University of California, Davis
4:35 pm Discussion

4:45 - Roundtable Discussion -- Consensus Building For
5:45 pm Sessions V and VI


Wednesday, May 3

VII. Biomonitoring and Population-Based Studies
Harri Vainio, Chair (Invite)
International Agency for Research on Cancer

A. Arctic Indigenous Health Studies
9:00 am Jay Van Oostdam, Health Canada
9:15 am Eric Dewailly, Public Health Center, Quebec
9:30 am John Middaugh, Department of Health and Social Services
9:45 am Discussion

B. Awasaki/Mohawk Tribe Studies
9:55 am David Carpenter, State University of New York, Albany
10:10 am Ron Scrudato, State University of New York, Oswego
10:25 am Discussion
10:35 am Coffee Break

C. Faroe Island Study
10:55 am Phillippe Grandjean, University of Southern Denmark
11:05 am Discussion

D. Exposure to POPs and Other Congeners
11:10 am Stephen Safe, Texas A&M University
11:25 am Ake Bergman, Stockholm University
11:40 am Georg Becher, National Institute of Public Health
11:55 am
12:10 pm Discussion

12:20 - Lunch
1:20 pm

E. Biomarkers in Wildlife
1:20 pm John Giesy, Michigan State University
1:35 pm Cristina Fossi, University of Siena
1:50 pm Jan Everaarts, Netherlands Institute for Sea Research
(Invite)
2:05 pm Discussion

F. Strategies for Validation Studies of New and Emerging Biomarkers
2:15 pm David Hunter, Harvard University
2:30 pm Chris Wild, University of Leeds
2:45 pm John Groopman, Johns Hopkins University
3:00 pm James Swenberg, University of North Carolina, Chapel Hill
3:15 pm Discussion

3:25 - Roundtable Discussion - Consensus Building For
4:25 pm Session V

VIII. Overview and Summation
4:25 pm Bernard D. Goldstein, Environmental and Occupational Health
Sciences Institute, University of Medicine and Dentistry,
New Jersey
5:00 pm Discussion

IX. Closing Remarks
5:10 pm William A. Suk, National Institute of Environmental Health
Sciences, NIH
Samuel H. Wilson, National Institute of Environmental Health
Sciences, NIH
5:20 pm Adjourn